Clinical Trials

Mouthwash

We conducted a double blind controlled study on 100 betel users over 14-days. We compared two potential Zingo formulas against a control group (coloured water). An excerpt from the final clinical report is attached below:

SENSITIVITY:

For between-treatment analysis all treatment groups showed a statistically significant reduction (p<0.05) in the level of sensitivity. The comparative control group (water) showed the least variation between treatment points whilst test article 1 showed the greatest level of variation. This would indicate that current market practice of rinsing with water is not as effective as either test articles and supports claims that ‘Test Article 1 and 2 significantly improve sensitivity’ and ‘Test Article 1 and 2 are more effective than water at improving sensitivity’.

This is also supported by the within treatment analysis, where observations recorded a highly statistically significant variation between the improvements shown by both test articles compared with water (p<0.001).

STAINING:

Between-treatment analysis of staining showed no statistically significant difference for the control group for pre and post treatment evaluations of staining.

Both test article 1 and 2 showed statistically significant reduction in staining, as determined by direction mean values (p<0.05), under between-treatment comparisons. This supports claims that `Test article 1 and 2 significantly reduce staining caused by chewing betel’.

Test article 1 showed a significant difference to article 2 under within-treatment comparisons of staining. The mean differences indicating that test article 1 was more effective at reducing the level of staining observed.

SPQs:

SPQ data showed subject favourability for all 3 products as expected to support quantifiable data.

CONCLUSION

It can be concluded that for both of the test articles the claims of “Reduces staining”, “Reduces sensitivity”, “More effective than water”, “Significantly reduces staining/Sensitivity”, “Dentist Recommended” and “Dentist Approved” are valid.

Chewing Gum

We have conducted 2 clinical trials working with leading Myanmar dentists and an independent clinical research scientist.

We received positive results from our recent clinical trial on our chewing gum. The conclusions from the draft report are below. Please note, we used a leading global sugar free gum, as our control group.

DATA DISCUSSION

Plaque, calculous and inflammation:

Both articles showed statistically significant reduction in the level of plaque, calculous and inflammation (p>0.05) as would be expected. Within treatment comparisons showed no significant variation between test groups’ mean differences of variation in any of the areas noted. The mean results show that the test article performed with greater levels of efficacy compared to the control product for both plaque and inflammation reduction.

SENSITIVITY:

For between-treatment analysis all treatment groups showed a statistically significant reduction (p<0.05) in the level of sensitivity. The control group showed the least variation between treatment points whilst test article 1 showed the greatest level of variation, the test article showing greater efficacy in reducing sensitivity.

STAINING:

The test article showed statistically significant reduction in staining, as determined by direction mean values (p<0.05), under between-treatment comparisons. This supports claims that ‘The Test Article significantly reduce staining caused by chewing betel’.

SPQs:

SPQ data showed subject favourability for both products as expected to support quantifiable data.

CONCLUSION

It can be concluded that the claims of “Reduces inflammation”, “Whitens teeth”, “Reduces pain”, “Reduces sensitivity”, “Reduces plaque”, “Improves betel chewers’ oral health/hygiene”, “Dentist Recommended” and “Dentist Approved” are valid for the test article.

Galleries

BEFORE (Day 1)
BEFORE (Day 1)

In this photo, staining is visible across all teeth. At this stage, this chewer had never used Zingo gum.

AFTER (Day 14)
AFTER (Day 14)

In this photo there are very noticeable reductions to staining along the top teeth, and some improvements to the bottom teeth. This chewer is continuing to use Zingo gum daily, and we will share further photos over time.